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Friday, July 31, 2020 | History

2 edition of Quantitation of nuclear aberrations as a screen for agents damaging to mammary epithelium. found in the catalog.

Quantitation of nuclear aberrations as a screen for agents damaging to mammary epithelium.

Sheila Marie Sharkey

Quantitation of nuclear aberrations as a screen for agents damaging to mammary epithelium.

by Sheila Marie Sharkey

  • 100 Want to read
  • 10 Currently reading

Published .
Written in English


The Physical Object
Pagination50 leaves
Number of Pages50
ID Numbers
Open LibraryOL19539802M

Additionally, markers of DNA damage, such as H2AFX, and impaired homologous recombination, such as RAD51 foci formation, may be predictive of therapeutic response to certain DNA-damaging chemotherapy agents and poly (adenosine diphosphate-ribose) polymerase inhibitors, respectively. ,– Next-generation sequencing has identified. An illustration of an open book. Books. An illustration of two cells of a film strip. Video. An illustration of an audio speaker. Audio. An illustration of a " floppy disk. Software. An illustration of two photographs. Images. An illustration of a heart shape Donate. An illustration of text ellipses.

  GENERAL PATHOLOGY MADE EASY 32 CELLUL AGING Agingis a process that results from the following factors. Accumulation of DNA Damage: Defective DNA repair mechanisms result in accumulation of damage caused by free radicals over a prolonged period of time. Replicative Senescence: Reduced ability of cells to divide because of decreasing amount of. During a split field test for longitudinal displacement of the collimator for jaw symmetry, the collimator is rotated through an angle of: % Tumor Control/% normal tissue Damage or Normal tissue tolerance dose/Tumor lethal dose. Region of Internal Mammary Lymph Nodes. Lateral Border of the Sternum.

Sheep nuclear transfer is dictated by the natural breeding season and so the question could not be resolved until the next year. The original plan for was to use embryonic cells again and also test whether the technique could be extended to cells at a later developmental stage, fibroblasts from .   Introduction. Nuclear morphology is an important feature associated with cellular function and disease. Enlargement of nuclei, anisokaryosis, nuclear pleomorphism, changes in chromatin patterns and nucleolar abnormalities are well-recognized features of neoplastic cells in human [1–3] as well as animal tumours [4–7].The quantitative assessment of variability of nuclear features in.


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Quantitation of nuclear aberrations as a screen for agents damaging to mammary epithelium by Sheila Marie Sharkey Download PDF EPUB FB2

The early nuclear damage caused by two known breast carcinogens, radiation and 7, dimethylbenzanthracene (DMBA), was quantitated by scoring for nuclear aberrations in mammary epithelium. Seven-week-old C57BL/6J female mice were irradiated with whole body gamma radiation or were given various doses of by: Quantitation of nuclear aberrations as a screen for agents damaging to mammary epithelium.

Sharkey SM, Bruce WR. The early nuclear damage caused by two known breast carcinogens, radiation and 7,dimethylbenzanthracene (DMBA), was quantitated by scoring for nuclear aberrations in mammary by: Sharkey SM, Bruce WR.

Quantitation of nuclear aberrations as a screen for agents damaging to mammary epithelium. Carcinogenesis. Dec; 7 (12)– Schop RN, Goldberg MT. Nongenotoxicity of minoxidil in murine hair follicles as determined by the nuclear aberration assay.

Toxicol Appl Pharmacol. Jan; 92 (1)–Cited by: 1. Nuclear aberrations are morphological endpoints visible with light microscopy 24 hours after carcinogen treatment (Wargovich et al., ).

These endpoints include micronuclei (Heddle, ; Schmid, Cited by: 4. M. Sharkey, R. BruceQuantitation of nuclear aberrations as a screen for agents damaging to mammary epithelium Carcinogenesis, 7 (), pp.

Google ScholarCited by:   Quantitation of nuclear aberrations as a screen for agents damaging to mammary epithelium. Carcinogenesis 7, S.M. Sharkey, W.R. BruceQuantitation of nuclear aberrations as a screen for agents damaging to mammary epithelium.

Carcinogenesis, 7 (), pp. Google Scholar. Silver et al., Quantitation of nuclear aberrations as a screen for agents damaging to mammary epithelium Association of gene expression with sequential proliferation, differentiation and tumor formation in.

The early nuclear damage caused by two known breast carcinogens, radiation and 7,dimethylbenzanthracene (DMBA), was quantitated by scoring for nuclear aberrations in mammary epithelium. The toxic effect of cyclophosphamide on the proliferative cell population of hair follicles plucked from the human scalp was examined by the in vivo nuclear aberration assay.

Patients participating in an independent clinical trial received oral low dose cyclophosphamide, intravenous high dose cyclophosphamide or oral placebo treatment.

The percent of cells with nuclear aberrations. Mammary epithelium was (p test) rescuing the DNA damage defect but it is important to note that our data suggest that any DNA damaging agent.

Lyle BJ, Mares-Perlman JA, Klein BE, et al. Antioxidant intake and risk of incident age-related nuclear cataracts in the Beaver Dam Eye Study. Am J Epidemiol ; View abstract. Nuclear factor-erythroid 2–related factor 2 (Nrf2) is a key transcriptional regulator for antioxidant and anti-inflammation enzymes that binds to its endogenous inhibitor protein, Kelch-like ECH (erythroid cell-derived protein with CNC homology)-associated protein 1, in the cytoplasm under normal conditions.

Various endogenous or environmental oxidative stresses, such as ionizing radiation. Emerging data suggest that metastasis-associated protein 1 (MTA1) represses ligand-dependent transactivation functions of estrogen receptor-alpha in cultured breast cancer cells and that MTA1 is upregulated in human breast tumors.

However, the role of MTA1 in tumorigenesis in a physiologically relevant animal system remains unknown. To reveal the role of MTA1 in mammary gland.

The objective of the study was the investigation of the behaviour of cathelicidin-1 in the milk after experimental infection with two prominent bacterial pathogens (experiment 1: Mannheimia haemolytica, experiment 2: M.

haemolytica and Staphylococcus chromogenes) as a potential early indicator for diagnosis of mastitis in sheep. In two experiments, after bacterial inoculation into the udder of. The alterations of the surface epithelium include the following clinical and pathologic terms: Leukoplakia is a clinical term that describes any white lesion on a.

Hypoxia is a hallmark of solid tumors [1,2].It occurs because the tumor neo-vasculature that develops from the host vascular supply via angiogenesis [] is a primitive and chaotic system that is unable to meet the oxygen demands of the growing tumor mass [2,4].As a consequence, cells that are distant from the blood vessels and at the limit of the diffusion distance of oxygen become chronically.

The hyperphosphorylation and relocalization of BRCA1 with RAD51 to PCNA-containing foci after exposure to DNA-damaging agents suggest an additional or alternate function for this protein. RAD51 has been implicated in DNA repair, as demonstrated by the high sensitivity to DNA-damaging agents of Saccharomyces cerevisiae rad51 mutants (17, Abstract.

The LC 50 of commercial neem extract (Sadao Thai III containing azadirachtin; NEEM) on filter paper in the earthworm Pheretima peguana at 48 h and 72 h was and g, earthworms exposed to five NEEM concentrations from (~10% of h LC 50) to (~80% of h LC 50) g, the radial thickness of the epidermis and body wall significantly decreased, and.

Calculation (or Calc) Book – A book used to look up factors used in MU calculation like TMR, PDD, Sc, Sp, (6x and 18x) (6x and 18x) Calculation Point (also called: Calc Point or Reference Point) – a reference point inside the PTV (at the intersection of the beam axes if possible) where the prescription dose is calculated.

From studies on the ERβ−/− mouse mammary gland, it appears that ERβ positively regulates the terminal differentiation of the mammary gland epithelium. The loss of ERβ results in a reduction of the ECM and lamina basalis and, frequently, in an increase of the interepithelial cell space, characterized by decreased levels of the adhesion.

Point mutations- the replacement of a single nucleotide base with another nucleotide. 2. Frameshift mutations- addition or deletion of a nucleotide such that the protein sequence from that point onward is altered. 3. Chromosomal aberrations- any change in the normal structure or number of chromosomes 4.Earthworms (Pheretima peguana, Lumbricidae, Oligochaeta) were sourced from a commercial worms were maintained in large plastic boxes (containing moist soil supplemented with cow dung) in the laboratory at 28 ± 1 °C and 65% humidity, with a 12 h light/dark cycle and fed weekly with watermelon and acclimatized for 2 weeks.

Adult worms (identified by the presence of a clitellum.This banner text can have markup. web; books; video; audio; software; images; Toggle navigation.